We delved into the complex relationship between vitamin D and glioma, particularly amid the challenges COVID-19 poses for patients with this aggressive brain cancer. Through our investigation, we identified 203 genes that were commonly altered in both glioma and COVID-19 infections. Among these, we pinpointed six key genes that can influence patient outcomes, including MYBL2, RBM6, VEPH1, AHNAK2, GNG10, and DUSP14.
After further examination, five of these genes showed potential interactions with vitamin D, suggesting that this vitamin might play a role in improving the prognosis for glioma patients who contract COVID-19. Specifically, vitamin D appears to influence the PI3K-Akt signaling pathway, which is critical in regulating numerous cellular functions linked to cancer progression.
Our molecular docking and single-cell RNA analyses indicate that vitamin D could help enhance the health and longevity of glioma patients during COVID-19 infections. However, it’s essential to note that while we observed potential benefits, the complex interplay between these factors warrants further research for a clearer understanding. Overall, this study sheds light on the promising connections between vitamin D, glioma, and COVID-19, paving the way for future treatment strategies.