' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 4 Researches
8
USERS' SCORE
Very Good
Based on 2 Reviews
8.4
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
8
Vitamin D treatment shows promise
Molecular Determinants of Calcitriol Signaling and Sensitivity in Glioma Stem-like Cells.
Study highlights vitamin D efficacy
We investigated the effects of vitamin D, specifically its active form calcitriol, on glioblastoma, the most common type of primary brain cancer in adults. With very limited treatment options and a grim prognosis, glioblastoma poses a serious challenge due to its ability to develop resistance to therapies and acquire stem-like properties that fuel its growth.
In our study, we treated glioblastoma stem-like cells in the lab with calcitriol and discovered some promising results. Among the more than 40 cell cultures we examined, approximately half showed sensitivity to the treatment. Notably, for a quarter of these cell lines, the response was classified as particularly strong.
We found that the effectiveness of calcitriol in reducing tumor growth and blocking stem-like traits could be linked to specific genetic variations in the vitamin D receptor. Importantly, the high responders displayed characteristics indicating reduced potential for both stemness and migration, which are key factors in tumor aggressiveness.
In our study, we treated glioblastoma stem-like cells in the lab with calcitriol and discovered some promising results. Among the more than 40 cell cultures we examined, approximately half showed sensitivity to the treatment. Notably, for a quarter of these cell lines, the response was classified as particularly strong.
We found that the effectiveness of calcitriol in reducing tumor growth and blocking stem-like traits could be linked to specific genetic variations in the vitamin D receptor. Importantly, the high responders displayed characteristics indicating reduced potential for both stemness and migration, which are key factors in tumor aggressiveness.
Read More
8
Vitamin D's role in glioma treatment
The Immunomodulatory Effects of Vitamin D on COVID-19 Induced Glioblastoma Recurrence via the PI3K-AKT Signaling Pathway.
Study highlights complex interactions
We delved into the complex relationship between vitamin D and glioma, particularly amid the challenges COVID-19 poses for patients with this aggressive brain cancer. Through our investigation, we identified 203 genes that were commonly altered in both glioma and COVID-19 infections. Among these, we pinpointed six key genes that can influence patient outcomes, including MYBL2, RBM6, VEPH1, AHNAK2, GNG10, and DUSP14.
After further examination, five of these genes showed potential interactions with vitamin D, suggesting that this vitamin might play a role in improving the prognosis for glioma patients who contract COVID-19. Specifically, vitamin D appears to influence the PI3K-Akt signaling pathway, which is critical in regulating numerous cellular functions linked to cancer progression.
Our molecular docking and single-cell RNA analyses indicate that vitamin D could help enhance the health and longevity of glioma patients during COVID-19 infections. However, it’s essential to note that while we observed potential benefits, the complex interplay between these factors warrants further research for a clearer understanding. Overall, this study sheds light on the promising connections between vitamin D, glioma, and COVID-19, paving the way for future treatment strategies.
After further examination, five of these genes showed potential interactions with vitamin D, suggesting that this vitamin might play a role in improving the prognosis for glioma patients who contract COVID-19. Specifically, vitamin D appears to influence the PI3K-Akt signaling pathway, which is critical in regulating numerous cellular functions linked to cancer progression.
Our molecular docking and single-cell RNA analyses indicate that vitamin D could help enhance the health and longevity of glioma patients during COVID-19 infections. However, it’s essential to note that while we observed potential benefits, the complex interplay between these factors warrants further research for a clearer understanding. Overall, this study sheds light on the promising connections between vitamin D, glioma, and COVID-19, paving the way for future treatment strategies.
Read More
8
Vitamin D linked to better survival
Optimal vitamin D status at admission appears to improve survival after craniotomy in patients with brain malignancies.
Study directly evaluates vitamin D's impact
We examined the connection between vitamin D levels and survival rates in patients undergoing craniotomy for brain malignancies. In this study, 56 patients participated, divided into three groups: one receiving a high dose of vitamin D, a control group without treatment, and a group with optimal vitamin D levels at admission.
Our findings revealed that patients with optimal vitamin D levels at admission had significantly better survival rates compared to those in the other groups. Specifically, the average vitamin D levels were notably higher for those with optimal status, indicating a potential link between higher vitamin D levels and improved outcomes after brain surgery.
Additionally, we discovered that total calcium levels and age also played important roles in predicting mortality risk. While the correlation between vitamin D levels and improved survival is promising, we suggest that further studies are needed to explore this important area of research more deeply.
Our findings revealed that patients with optimal vitamin D levels at admission had significantly better survival rates compared to those in the other groups. Specifically, the average vitamin D levels were notably higher for those with optimal status, indicating a potential link between higher vitamin D levels and improved outcomes after brain surgery.
Additionally, we discovered that total calcium levels and age also played important roles in predicting mortality risk. While the correlation between vitamin D levels and improved survival is promising, we suggest that further studies are needed to explore this important area of research more deeply.
Read More
Most Useful Reviews
8.8
Essential medication
I take this small capsule three times a week to maintain my levels. I undergo a blood test annually, and my doctor determines the appropriate dosage. I have a rare condition, Fahr's disease, which calcifies my brain, necessitating precise dosage to support my treatment for the brain tumour.
Read More
8
Supports brain health
Good for bone, skin, and brain.
Read More
Most Recommended Products for Brain Tumor
Doctor's Best Nattokinase
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 2 Reviews
9.5
NOW Foods Quercetin with Bromelain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 2 Reviews
9.2
Qunol Mega CoQ10 Ubiquinol
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 4 Reviews
9
Medical Researches
SCIENTIFIC SCORE
Most Likely Effective
Based on 4 Researches
8
8
Vitamin D3 boosts glioblastoma treatment
Enhanced Antiglioma Effect by a Vitamin D3-Inserted Lipid Hybrid Neutrophil Membrane Biomimetic Multimodal Nanoplatform.
Potential treatment strategy explored
We developed an innovative method to tackle glioblastoma, a particularly aggressive brain tumor. Our approach involved creating a unique nanoplatform that combines vitamin D3, lipids, and neutrophil membranes to enhance the treatment's effectiveness.
Through this method, we incorporated doxorubicin-loaded manganese dioxide nanoparticles, which not only provided chemotherapy but also activated immune responses. Impressively, this nanoplatform significantly boosted the body's immune reaction, stimulating the release of type I interferon-β and inflaming cytokines to target glioma tissues.
We observed a transformation in the tumor's environment, shifting from an immunosuppressive "cold" tumor to a more responsive "hot" tumor, thereby increasing the presence of crucial immune cells like CD8T cells. Although the specific isolated effects of vitamin D3 on its own cannot be determined from this study, its synergistic role within this multimodal strategy showcases promising potential for future cancer treatments, particularly in harnessing the body's innate immune responses against glioblastoma.
Through this method, we incorporated doxorubicin-loaded manganese dioxide nanoparticles, which not only provided chemotherapy but also activated immune responses. Impressively, this nanoplatform significantly boosted the body's immune reaction, stimulating the release of type I interferon-β and inflaming cytokines to target glioma tissues.
We observed a transformation in the tumor's environment, shifting from an immunosuppressive "cold" tumor to a more responsive "hot" tumor, thereby increasing the presence of crucial immune cells like CD8T cells. Although the specific isolated effects of vitamin D3 on its own cannot be determined from this study, its synergistic role within this multimodal strategy showcases promising potential for future cancer treatments, particularly in harnessing the body's innate immune responses against glioblastoma.
Read More
8
Vitamin D's role in glioma treatment
The Immunomodulatory Effects of Vitamin D on COVID-19 Induced Glioblastoma Recurrence via the PI3K-AKT Signaling Pathway.
Study highlights complex interactions
We delved into the complex relationship between vitamin D and glioma, particularly amid the challenges COVID-19 poses for patients with this aggressive brain cancer. Through our investigation, we identified 203 genes that were commonly altered in both glioma and COVID-19 infections. Among these, we pinpointed six key genes that can influence patient outcomes, including MYBL2, RBM6, VEPH1, AHNAK2, GNG10, and DUSP14.
After further examination, five of these genes showed potential interactions with vitamin D, suggesting that this vitamin might play a role in improving the prognosis for glioma patients who contract COVID-19. Specifically, vitamin D appears to influence the PI3K-Akt signaling pathway, which is critical in regulating numerous cellular functions linked to cancer progression.
Our molecular docking and single-cell RNA analyses indicate that vitamin D could help enhance the health and longevity of glioma patients during COVID-19 infections. However, it’s essential to note that while we observed potential benefits, the complex interplay between these factors warrants further research for a clearer understanding. Overall, this study sheds light on the promising connections between vitamin D, glioma, and COVID-19, paving the way for future treatment strategies.
After further examination, five of these genes showed potential interactions with vitamin D, suggesting that this vitamin might play a role in improving the prognosis for glioma patients who contract COVID-19. Specifically, vitamin D appears to influence the PI3K-Akt signaling pathway, which is critical in regulating numerous cellular functions linked to cancer progression.
Our molecular docking and single-cell RNA analyses indicate that vitamin D could help enhance the health and longevity of glioma patients during COVID-19 infections. However, it’s essential to note that while we observed potential benefits, the complex interplay between these factors warrants further research for a clearer understanding. Overall, this study sheds light on the promising connections between vitamin D, glioma, and COVID-19, paving the way for future treatment strategies.
Read More
8
Vitamin D treatment shows promise
Molecular Determinants of Calcitriol Signaling and Sensitivity in Glioma Stem-like Cells.
Study highlights vitamin D efficacy
We investigated the effects of vitamin D, specifically its active form calcitriol, on glioblastoma, the most common type of primary brain cancer in adults. With very limited treatment options and a grim prognosis, glioblastoma poses a serious challenge due to its ability to develop resistance to therapies and acquire stem-like properties that fuel its growth.
In our study, we treated glioblastoma stem-like cells in the lab with calcitriol and discovered some promising results. Among the more than 40 cell cultures we examined, approximately half showed sensitivity to the treatment. Notably, for a quarter of these cell lines, the response was classified as particularly strong.
We found that the effectiveness of calcitriol in reducing tumor growth and blocking stem-like traits could be linked to specific genetic variations in the vitamin D receptor. Importantly, the high responders displayed characteristics indicating reduced potential for both stemness and migration, which are key factors in tumor aggressiveness.
In our study, we treated glioblastoma stem-like cells in the lab with calcitriol and discovered some promising results. Among the more than 40 cell cultures we examined, approximately half showed sensitivity to the treatment. Notably, for a quarter of these cell lines, the response was classified as particularly strong.
We found that the effectiveness of calcitriol in reducing tumor growth and blocking stem-like traits could be linked to specific genetic variations in the vitamin D receptor. Importantly, the high responders displayed characteristics indicating reduced potential for both stemness and migration, which are key factors in tumor aggressiveness.
Read More
8
Vitamin D linked to better survival
Optimal vitamin D status at admission appears to improve survival after craniotomy in patients with brain malignancies.
Study directly evaluates vitamin D's impact
We examined the connection between vitamin D levels and survival rates in patients undergoing craniotomy for brain malignancies. In this study, 56 patients participated, divided into three groups: one receiving a high dose of vitamin D, a control group without treatment, and a group with optimal vitamin D levels at admission.
Our findings revealed that patients with optimal vitamin D levels at admission had significantly better survival rates compared to those in the other groups. Specifically, the average vitamin D levels were notably higher for those with optimal status, indicating a potential link between higher vitamin D levels and improved outcomes after brain surgery.
Additionally, we discovered that total calcium levels and age also played important roles in predicting mortality risk. While the correlation between vitamin D levels and improved survival is promising, we suggest that further studies are needed to explore this important area of research more deeply.
Our findings revealed that patients with optimal vitamin D levels at admission had significantly better survival rates compared to those in the other groups. Specifically, the average vitamin D levels were notably higher for those with optimal status, indicating a potential link between higher vitamin D levels and improved outcomes after brain surgery.
Additionally, we discovered that total calcium levels and age also played important roles in predicting mortality risk. While the correlation between vitamin D levels and improved survival is promising, we suggest that further studies are needed to explore this important area of research more deeply.
Read More
User Reviews
USERS' SCORE
Very Good
Based on 2 Reviews
8.4
8.8
Essential medication
I take this small capsule three times a week to maintain my levels. I undergo a blood test annually, and my doctor determines the appropriate dosage. I have a rare condition, Fahr's disease, which calcifies my brain, necessitating precise dosage to support my treatment for the brain tumour.
Read More
8
Supports brain health
Good for bone, skin, and brain.
